Table 4.
Antioxidant activity of HBNs 5–9, PBN, Trolox and NDGA.
| HBNs/standards | ClogPa | ILPO (%) | LOX inhibition (IC50 [μM]/%) | Scav. activity for ·OH (%) | ABTS+. (%) |
|---|---|---|---|---|---|
| PBN | 3.02 | 11 | 23 | no | 5 |
| HBN5 | 4.51 | 55 | 6 | 67 | no |
| HBN6 | 4.96 | 37 | 29 | 81 | no |
| HBN7 | 2.56 | 64 | 60 µM | 29 | 22 |
| HBN8 | 0.61 | 46 | 57.5 µM | 59 | 4 |
| HBN9 | 4.95 | 80 | 85 µM | 16 | 23 |
| NDGA | nd | nd | 0.45 µM | nd | nd |
| Trolox | nd | 88 | nd | 83 | 91 |
Bold is for emphasis
Nitrones tested at 100 µM; Values are means of three or four different determinations. No, no activity under the experimental conditions. Means within each column differ significantly (P < 0.05).
nd not determined, no no activity.
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