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. 2020 Aug 25;10:14180. doi: 10.1038/s41598-020-71027-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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α₂ haploinsufficiency alters Cox1 and Cox2 gene expression in astrocytes from the hypothalamus and hippocampus of α₂^+/+ mice and α₂^+/G301R mice. (a–d). qPCR mRNA expression analysis for Cox1 (a,b); Cox2 (c,d). All data are the mean ± SEM of three individual experiments. *p < 0.05, *p < 0.01, and ***p < 0.001 (Kruskal–Wallis test followed by Dunn’s post hoc test, n = 3 mice/group).