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. 2020 Aug 25;11:4078. doi: 10.1038/s41467-020-17930-x

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© The Author(s) 2020, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Naive mice (8~12 months old males) serve as a control group (circles, n = 6). Stroke mice (8~12 months old males) underwent tMCAO for 90 min. The occlusion and reperfusion were confirmed by a laser speckle imager. Stroke mice were then randomized into four groups: two groups being killed at 8 (squares, n = 6) and 23 h (diamonds, n = 6) post stroke; two groups receiving blood replacement (BR) therapy and being killed at 8 (down-pointing triangles, n = 6) and 23 h (up-pointing triangles, n = 6) post stroke. Then plasma was collected for the analyses of proinflammatory cytokine panel including IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IFN-γ, TNF-α, and the chemokine, CXCL1. Data were presented as means ± SEM. One-way ANOVA followed by post hoc Fisher’s unprotected least-significant difference for multiple comparison tests. Source data are provided as a Source Data file.