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. 2020 Jul 24;34(9):973–988. doi: 10.1007/s40263-020-00749-x
Using four definitions of highly active disease (HAD) with varying criteria, alemtuzumab improved outcomes in patients with HAD, and efficacy was maintained over 9 years in highly active relapsing-remitting multiple sclerosis.
Efficacy in the HAD population was generally consistent with and similar to the overall Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis (CARE-MS) population.
No new safety signals were seen in alemtuzumab-treated patients with HAD over 9 years.