Table 3.
Dose proportionality of aripiprazole following the last dose (PK population)
| Patients (n) | Intercept | Slope | |||||
|---|---|---|---|---|---|---|---|
| Estimate | SE | 90% CI | Estimate | SE | 90% CI | ||
| AUClast, (day·ng/mL) | 79 | 7.70 | 1.26 | 5.60–9.80 | 0.249 | 1.04 | − 1.49 to 1.99 |
| Cmax, ng/mL | 79 | 3.27 | 1.20 | 1.26–5.27 | 0.267 | 1.00 | − 1.39 to 1.93 |
PK parameters (Y) were analyzed using a power model: log (Y) = intercept + slope × log (dose)
AUClast area under the plasma drug concentration–time curve from time zero until the last measurable plasma drug concentration time point, CI confidence interval, Cmax maximum plasma drug concentration, PK pharmacokinetics, SE standard error