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. 2020 Jun 7;69(3):670–681. doi: 10.1007/s12020-020-02355-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Comparison of endocrine ADRs in different ICI therapies. a P1 vs. C4: anti-PD-1/PD-L1 monotherapy vs. anti-CTLA-4 monotherapy. b P1C4 vs. P1/C4: anti-PD-1/PD-L1 combined with anti-CTLA-4 vs. anti-PD-1/PD-L1 monotherapy and anti-CTLA-4 monotherapy. On the analysis of ROR, a minimum count of drug-adverse reaction (N ≥ 3) was imposed. SIADH inappropriate antidiuretic hormone secretion, secondary ACI secondary adrenocortical insufficiency, adrenal crisis acute adrenocortical insufficiency, fulminant T1DM fulminant type 1 diabetes mellitus