Fig. 3.

Effects of maternal PETN treatment on blood pressure in HFD-fed F1 DSSR. F0 DSSR were treated with or without PETN (50 mg/kg/day) during pregnancy and lactation periods. F1 male DSSR received either normal chow (NCD) or high-fat diet (HFD) (45% kcal from fat) starting at the age of 5 weeks. Systolic blood pressure (SBP) (a), diastolic blood pressure (DBP) (b) and mean arterial pressure (MAP) (c) were measured in the offspring at age of 5 weeks and 16 weeks. The symbols represent mean ± SEM, n = 10–19. Student’s t test was used for comparison. **P < 0.01, ***P < 0.001, vs control-NCD group. ^###P < 0.001 vs PETN-NCD group