Table 3.

Pearson correlation testing per patient—PRx versus L-PRx variants

Patient	Pearson correlation coefficients
	PRx versus L-PRx_5	P	PRx versus L-PRx_10	P	PRx versus L-PRx_20	P	PRx versus L-PRx_30	P	PRx versus L-PRx_40	P	PRx versus L-PRx_60	P
1	0.738	p < 0.0001	0.305	p < 0.0001	0.229	p < 0.0001	0.180	p < 0.0001	0.146	p < 0.0001	0.127	p < 0.0001
2	0.681	p < 0.0001	0.289	p < 0.0001	0.207	p < 0.0001	0.169	p < 0.0001	0.149	p < 0.0001	0.117	p < 0.0001
3	0.667	p < 0.0001	0.280	p < 0.0001	0.200	p < 0.0001	0.178	p < 0.0001	0.131	p < 0.0001	0.114	p < 0.0001
4	0.827	p < 0.0001	0.311	p < 0.0001	0.195	p < 0.0001	0.147	p < 0.0001	0.132	p < 0.0001	0.094	p < 0.0001
5	0.756	p < 0.0001	0.259	p < 0.0001	0.167	p < 0.0001	0.101	p < 0.0001	0.092	p < 0.0001	0.085	p < 0.0001
6	0.660	p < 0.0001	0.290	p < 0.0001	0.217	p < 0.0001	0.163	p < 0.0001	0.131	p < 0.0001	0.117	p < 0.0001
7	0.642	p < 0.0001	0.328	p < 0.0001	0.295	p < 0.0001	0.269	p < 0.0001	0.240	p < 0.0001	0.213	p < 0.0001
8	0.730	p < 0.0001	0.313	p < 0.0001	0.222	p < 0.0001	0.183	p < 0.0001	0.159	p < 0.0001	0.129	p < 0.0001
9	0.661	p < 0.0001	0.302	p < 0.0001	0.209	p < 0.0001	0.155	p < 0.0001	0.129	p < 0.0001	0.086	p < 0.0001
10	0.746	p < 0.0001	0.289	p < 0.0001	0.224	p < 0.0001	0.197	p < 0.0001	0.157	p < 0.0001	0.109	p < 0.0001
11	0.688	p < 0.0001	0.275	p < 0.0001	0.206	p < 0.0001	0.145	p < 0.0001	0.113	p < 0.0001	0.100	p < 0.0001
12	0.737	p < 0.0001	0.276	p < 0.0001	0.262	p < 0.0001	0.225	p < 0.0001	0.155	p < 0.0001	0.123	p < 0.0001
13	0.718	p < 0.0001	0.284	p < 0.0001	0.234	p < 0.0001	0.214	p < 0.0001	0.202	p < 0.0001	0.166	p < 0.0001
14	0.689	p < 0.0001	0.269	p < 0.0001	0.220	p < 0.0001	0.196	p < 0.0001	0.163	p < 0.0001	0.105	p < 0.0001
15	0.703	p < 0.0001	0.269	p < 0.0001	0.174	p < 0.0001	0.157	p < 0.0001	0.123	p < 0.0001	0.087	p < 0.0001
16	0.647	p < 0.0001	0.292	p < 0.0001	0.211	p < 0.0001	0.171	p < 0.0001	0.152	p < 0.0001	0.118	p < 0.0001
17	0.712	p < 0.0001	0.321	p < 0.0001	0.249	p < 0.0001	0.211	p < 0.0001	0.186	p < 0.0001	0.144	p < 0.0001
18	0.682	p < 0.0001	0.280	p < 0.0001	0.164	p < 0.0001	0.111	p < 0.0001	0.070	p < 0.0001	0.066	p < 0.0001
19	0.801	p < 0.0001	0.322	p < 0.0001	0.246	p < 0.0001	0.105	p < 0.0001	0.125	p < 0.0001	0.018	p < 0.0001
20	0.749	p < 0.0001	0.303	p < 0.0001	0.234	p < 0.0001	0.198	p < 0.0001	0.186	p < 0.0001	0.153	p < 0.0001
21	0.720	p < 0.0001	0.254	p < 0.0001	0.149	p < 0.0001	0.121	p < 0.0001	0.095	p < 0.0001	0.054	p < 0.0001
22	0.645	p < 0.0001	0.298	p < 0.0001	0.212	p < 0.0001	0.162	p < 0.0001	0.163	p < 0.0001	0.128	p < 0.0001
23	0.581	p < 0.0001	0.312	p < 0.0001	0.265	p < 0.0001	0.259	p < 0.0001	0.243	p < 0.0001	0.210	p < 0.0001
24	0.793	p < 0.0001	0.274	p < 0.0001	0.1855	p < 0.0001	0.124	p < 0.0001	0.087	p < 0.0001	0.074	p < 0.0001
25	0.702	p < 0.0001	0.311	p < 0.0001	0.223	p < 0.0001	0.184	p < 0.0001	0.145	p < 0.0001	0.105	p < 0.0001
26	0.736	p < 0.0001	0.311	p < 0.0001	0.262	p < 0.0001	0.220	p < 0.0001	0.214	p < 0.0001	0.121	p < 0.0001
27	0.743	p < 0.0001	0.291	p < 0.0001	0.181	p < 0.0001	0.157	p < 0.0001	0.128	p < 0.0001	0.092	p < 0.0001
28	0.713	p < 0.0001	0.291	p < 0.0001	0.209	p < 0.0001	0.154	p < 0.0001	0.129	p < 0.0001	0.099	p < 0.0001
29	0.684	p < 0.0001	0.265	p < 0.0001	0.172	p < 0.0001	0.130	p < 0.0001	0.122	p < 0.0001	0.055	p < 0.0001
30	0.539	p < 0.0001	0.252	p < 0.0001	0.195	p < 0.0001	0.167	p < 0.0001	0.140	p < 0.0001	0.103	p < 0.0001
31	0.441	p < 0.0001	0.202	p < 0.0001	0.150	p < 0.0001	0.135	p < 0.0001	0.126	p < 0.0001	0.089	p < 0.0001

p-values are small given autocorrelation in min-by-min updated data. As such, one can only comment on the magnitude of the Pearson correlation coefficient, not the degree of statistical significance. Also, PRx and L-PRx variants tested were Fisher transformed de-trended (i.e. differenced) variables

P p-value, PRx pressure reactivity index (correlation between slow waves of ICP and MAP), L-PRx long PRx (correlation between min-by-min mean data for ICP and MAP; window length for correlation calculation varied, L-PRx_5 5 min window, etc