Table 3.
Odds ratios (OR) and 95% confidence intervals (CI) for hypertension in relation to rs3782886 genotype by reticulocyte levels.
| Major homo (A/A) | Hetero (A/G) | Minor homo (G/G) | p for trend | MAF | |
|---|---|---|---|---|---|
| Low reticulocyte | |||||
| No. of participants (%) | 380 (57.9) | 232 (35.4) | 44 (6.7) | ≥ 0.05* | |
| No. of expectations (%) | 375.02 (57.2) | 241.95 (36.9) | 39.02 (5.9) | ||
| No. of cases (%) | 213 (56.1) | 128 (55.2) | 24 (54.5) | ||
| Platelets, ×104 /μL | 22.3 ± 5.2 | 22.8 ± 4.7 | 23.0 ± 5.6 | 0.480 | – |
| Reticulocyte, ×104 cells/μL | 3.7 ± 0.7 | 3.8 ± 0.7 | 3.7 ± 0.8 | 0.790 | – |
| Model 1 | 1.00 | 0.98 (0.70, 1.39) | 0.95 (0.50, 1.81) | 0.872 | 0.98 (0.76, 1.27) |
| Model 2 | 1.00 | 1.13 (0.78, 1.65) | 0.96 (0.48, 1.92) | 0.753 | 1.05 (0.79, 1.39) |
| High reticulocyte | |||||
| No. of participants (%) | 395 (60.1) | 208 (31.7) | 54 (8.2) | ≥ 0.05* | |
| No. of expectations (%) | 379.00 (57.7) | 240.01 (36.5) | 38.00 (5.8) | ||
| No. of cases (%) | 271 (68.6) | 129 (62.0) | 28 (51.9) | ||
| Platelets, ×104 /μL | 22.2 ± 4.8 | 23.5 ± 4.9 | 23.7 ± 5.0 | 0.005 | – |
| Reticulocyte, ×104 cells/μL | 6.3 ± 1.8 | 6.2 ± 1.1 | 6.1 ± 1.0 | 0.407 | – |
| Model 1 | 1.00 | 0.72 (0.50, 1.03) | 0.49 (0.27, 0.88) | 0.007 | 0.71 (0.55, 0.91) |
| Model 2 | 1.00 | 0.71 (0.48, 1.06) | 0.53 (0.28, 1.02) | 0.025 | 0.72 (0.55, 0.96) |
Model 1: adjusted only for sex and age. Model 2: Adjusted further for sex, age, alcohol consumption (never drinker, former drinker, current drinker [23–45 g/week, 46–68 g/week, ≥ 69 g/week]) , smoking status (never smoker, former smoker, current smoker), body mass index, HDL-cholesterol, triglycerides, HbA1c, and GFR. The hypertension is defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg and/or taking anti-hypertensive medication. MAF: minor allele frequency.
*Hardy–Weinberg equilibrium p-values.