Table 4.
Odds ratios (OR) and 95% confidence intervals (CI) for hypertension in relation to rs671 genotype by reticulocyte levels.
| Major homo (G/G) | Hetero (G/A) | Minor homo (A/A) | p for trend | MAF | |
|---|---|---|---|---|---|
| Low reticulocyte | |||||
| No. of participants (%) | 394 (60.1) | 224 (34.1) | 38 (5.8) | ≥ 0.05* | |
| No. of expectations (%) | 390.30 (59.5) | 231.40 (35.3) | 34.30 (5.2) | ||
| No. of cases (%) | 219 (55.6) | 125 (55.8) | 21 (55.3) | ||
| Platelets, ×104 /μL | 22.3 ± 5.3 | 22.8 ± 4.5 | 23.0 ± 5.9 | 0.515 | – |
| Reticulocyte, ×104 cells/μL | 3.7 ± 0.7 | 3.8 ± 0.7 | 3.7 ± 0.8 | 0.876 | – |
| Model 1 | 1.00 | 1.02 (0.72, 1.44) | 0.98 (0.49, 1.94) | 0.983 | 1.00 (0.77, 1.31) |
| Model 2 | 1.00 | 1.16 (0.80, 1.69) | 1.04 (0.50, 2.15) | 0.588 | 1.08 (0.81, 1.45) |
| High reticulocyte | |||||
| No. of participants (%) | 413 (62.9) | 195 (29.7) | 49 (7.5) | ≥ 0.05* | |
| No. of expectations (%) | 396.67 (60.4) | 227.67 (34.7) | 32.67 (5.0) | ||
| No. of cases (%) | 281 (68.0) | 123 (63.1) | 24 (49.0) | ||
| Platelets, ×104 /μL | 22.2 ± 4.8 | 23.5 ± 4.9 | 24.0 ± 5.1 | 0.002 | – |
| Reticulocyte, ×104 cells/μL | 6.3 ± 1.8 | 6.1 ± 1.1 | 6.1 ± 1.0 | 0.249 | – |
| Model 1 | 1.00 | 0.79 (0.55, 1.14) | 0.46 (0.25, 0.85) | 0.012 | 0.72 (0.56, 0.93) |
| Model 2 | 1.00 | 0.75 (0.50, 1.12) | 0.50 (0.25, 0.98) | 0.027 | 0.72 (0.54, 0.96) |
Model 1: adjusted only for sex and age. Model 2: Adjusted further for sex, age, alcohol consumption (never drinker, former drinker, current drinker [23–45 g/week, 46-68 g/week, ≥ 69 g/week]) , smoking status (never smoker, former smoker, current smoker), body mass index, HDL-cholesterol, triglycerides, HbA1c, and GFR. The hypertension is defined as systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg and/or taking anti-hypertensive medication.
MAF: minor allele frequency.
*Hardy–Weinberg equilibrium p-values.