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. 2020 Aug 26;5:153. doi: 10.1038/s41392-020-0204-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The combination of BMS-754807 and U0126 significantly suppresses tumor growth in the HCT116 colon xenograft model. NCr nude mice (five mice per group) were treated with vehicle [10% (v/v) DMSO in corn oil], BMS-754807 (25 mg/kg, BMS), U0126 (15 mg/kg), or BMS-754807 + U0126 (25 mg/kg+15 mg/kg) for 12 days. a The tumor volume was measured every other day with calipers. Data were analyzed by one-way ANOVA with Dunnett’s multiple comparison versus vehicle, BMS-754807, or U0126 after 12-day treatment (mean ± SD; ^###P < 0.001). b Image of tumors after 12-day treatment. c The BMS-754807 + U0126 treatment significantly lowered the average tumor weight comparing to the vehicle, BMS-754807, or U0126 treatment. Data were analyzed by one-way ANOVA with Dunnett’s multiple comparison (mean ± SD; ^##P < 0.01; ^###P < 0.001). d Tumor sections were examined for proliferation (stained with Ki-67) and apoptosis (stained with TUNEL). The representative images are shown; scale bar, 10 μm. e, f The number of positive-staining cells in tumors in each treatment was calculated as the average number of four random images. The data were analyzed by one-way ANOVA with Dunnett’s multiple comparison (mean ± SD; ^###P < 0.001). BMS: BMS-754807