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. 2020 Aug 25;10:14149. doi: 10.1038/s41598-020-70941-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Validation of inferred GRNs’ topologies. Each x-axis tick mark shows the prediction performance in terms of the wRSS error of each inferred GRN topology (circles) fit to training data under cross-validation, compared to its shuffled topologies. The box displays the median and interquartile range, and whiskers bound points maximally extending 1.5 times this range. Beyond this, outlier points are shown.