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. 2020 Aug 25;10:14149. doi: 10.1038/s41598-020-70941-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NestBoot output for the overall best performing GRN. (A) Shows the entire bootstrap support range from 0 to 1, as well as overlap between all bootstrap GRNs for measured (blue) and shuffled (red) data. The FDR is estimated via a null background model based on networks inferred from shuffled data. This is done to restrict inclusion of false links by setting FDR e.g. to 5%. The dashed orange line represents the cutoff where this is reached, here at 97.5% bootstrap support. The dashed grey line shows how the FDR behaves as a function of the bootstrap support. (B) Shows the fine detail of the curves in the support levels between 0.9 and 1. These visualizations were made by the provided shiny app.