Table 2.
Association of biological factors with cognitive status in the full longitudinal PUC cohort.
| Coef. (OR)a | 95% CI (OR) | P | ||
|---|---|---|---|---|
| Age | 0.18 (1.20) | 0.15 (1.16) | 0.22 (1.24) | 2.64 × 10−26 |
| Disease duration | 0.15 (1.16) | 0.11 (1.12) | 0.19 (1.21) | 5.13 × 10−14 |
| Sex | 2.92 (18.54) | 2.30 (9.97) | 3.54 (34.47) | 2.80 × 10−20 |
| APOE | 0.23 (1.26) | −0.39 (0.68) | 0.85 (2.34) | 0.47 |
| GBA | 2.72 (15.18) | 1.94 (6.96) | 3.50 (33.11) | 1.00 × 10−11 |
| MAPT | −0.21 (0.81) | −0.80 (0.45) | 0.38 (1.46) | 0.48 |
APOE apolipoprotein E gene, CI confidence interval, GBA glucocerebrosidase gene, GDS-15 15-item Geriatric Depression Scale, LEDD levodopa equivalent daily dose, MAPT microtubule-associated protein tau gene, OR odds ratios, PUC Pacific Udall Center.
aModels adjusted for LEDD, GDS-15, site and years of education.