Table 3.

Association of APOE ε4 allele, GBA status, and MAPT haplotype with the cognitive performance in the full longitudinal PUC cohort.

Cognitive tests	Intercept	APOE				GBA				MAPT
	Random Intercept Std.	Coef.a	95% CI	P	Pc	Coef.a	95% CI	P	Pc	Coef.a	95% CI	P	Pc
Semantic verbal fluency	4.06	−1.11	−1.91 to −0.31	0.01	0.07	−1.83	−2.92 to −0.74	1.10 × 10−3	0.01	0.10	−0.66 to 0.85	0.80	>0.99
Phonemic verbal fluency	9.47	−1.46	−3.2 to 0.29	0.10	>0.99	−1.50	−3.87 to 0.86	0.22	>.99	−0.05	−1.7 to 1.6	0.95	>0.99
HVLT-R Total Recall	3.76	−0.38	−1.11 to 0.36	0.32	>0.99	−1.92	−2.92 to −0.92	1.84 × 10−4	1.84 × 10−3	0.58	−0.11 to 1.27	0.10	>0.99
HVLT-R RDI	1.30	0.00	−0.28 to 0.28	0.99	>0.99	−0.56	−0.94 to −0.18	4.12 × 10−3	0.04	0.11	−0.15 to 0.38	0.39	>0.99
HVLT-R Delayed recall	1.97	−0.07	−0.5 to 0.36	0.75	>0.99	−0.67	−1.25 to −0.08	0.03	0.27	0.36	−0.05 to 0.76	0.08	0.84
Judgment of line orientation	1.67	−0.44	−0.77 to −0.1	0.01	0.11	−0.99	−1.45 to −0.54	2.34 × 10−5	2.34 × 10−4	0.12	−0.19 to 0.44	0.45	>0.99
Digit symbol	8.97	−1.63	−3.29 to 0.03	0.06	0.56	−4.85	−7.1 to −2.6	2.98 × 10−5	2.98 × 10−4	0.27	−1.3 to 1.84	0.74	>0.99
Letter number sequencing	1.73	−0.11	−0.46 to 0.23	0.53	>0.99	−0.95	−1.42 to −0.48	9.28 × 10−5	9.28 × 10−4	0.35	0.02 to 0.67	0.04	0.37
TMT B – TMTA	40.27	4.50	−3.73 to 12.75	0.29	>0.99	31.47	20.21 to 42.72	6.74 × 10−8	6.74 × 10−7	−8.30	−16.09 to −0.53	0.04	0.32
MoCA	2.53	−0.37	−0.87 to 0.13	0.15	>0.99	−1.75	−2.43 to −1.07	7.24 × 10−7	7.24 × 10−6	0.20	−0.27 to 0.68	0.40	>0.99

P_c = Bonferroni corrected values.

APOE, apolipoprotein E gene, CI confidence interval, GBA glucocerebrosidase gene, GDS-15 15-item Geriatric Depression Scale, HVLT-R Hopkins Verbal Learning Test-Revised, LEDD levodopa equivalent daily dose, MAPT microtubule-associated protein tau gene, MoCA Montreal Cognitive Assessment, PUC Pacific Udall Center, RDI Recognition Discrimination Index, TMT Trailmaking Test.

^aModels adjusted for age, LEDD, GDS-15, disease duration, sex, site and years of education.