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. 2020 Aug 25;10:14156. doi: 10.1038/s41598-020-70824-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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No genetic interaction between ZNF148 and TP53 in human cancer cell lines. (A) Graph showing the median CRISPR and siRNA scores across the human cancer cell lines for all genes. ZNF148 scores are indicated by arrows. n = 17,631 (CRISPR) and 16,725 (siRNA) genes, respectively. (B) Graph showing the CRISPR and siRNA scores of ZNF148 for all cancer cell lines. n = 432 (CRISPR) and 328 (siRNA) cell lines, respectively. (C–E) Graphs showing the CRISPR scores of TP53 (C) or MDM2 (D) or ZNF148 (E) for cell lines with wild-type (left, n = 354) or mutated (right, n = 164) TP53. (F) Graphs showing Pearson correlation with CRISPR (left) or siRNA (right) scores of TP53 (y-axis) for all genes sorted by rank (x-axis). The position of ZNF148 is indicated by arrows. n = 17,631 (CRISPR) and 8,296 (siRNA) genes, respectively.