Table 4.
MICs (mg/l) of various antibiotics against antibiotic-resistant gram-positive and gram-negative bacteria in the absence and presence of di-F-Q.
| Antibiotics | Conc. of di-F-Q | MICs (mg/l) against various bacterial strainsa | ||||||
|---|---|---|---|---|---|---|---|---|
| Gram-positive | Gram-negative | |||||||
| MRSA (ST72) | hVISA | VRE | CRPA | CRAB | CRE KPC | CRE NDM-1 | ||
| AMP | 0 | 16 | 64 | 256 | –b | –b | –b | –b |
| MIC/4 | 16 | 32 | 128 | –b | –b | –b | –b | |
| CAZ | 0 | 256 | > 256 | > 256 | 16 | 256 | > 256 | > 256 |
| MIC/4 | 256 | > 256 | > 256 | 2c | 64c | > 256 | > 256 | |
| FEP | 0 | 64 | > 256 | > 256 | 64 | 64 | 256 | 8 |
| MIC/4 | 64 | > 256 | > 256 | 32c | 64c | 256 | 8 | |
| MER | 0 | –b | –b | –b | 16 | 64 | 256 | 4 |
| MIC/4 | –b | –b | –b | 16 | 64 | 256 | 4 | |
| VAN | 0 | 0.5 | 1 | > 256 | –b | –b | –b | –b |
| MIC/4 | 0.5 | 1 | > 256 | –b | –b | –b | –b | |
aShaded cells indicate MICs of the antibiotics decreased more than fourfold upon combination with di-F-Q.
bNot determined.
cConc. of di-F-Q = 32 mg/L.