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. 2020 Aug 25;10:14167. doi: 10.1038/s41598-020-70806-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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bves knockdown led to the phenotype of outflow tract stenosis in zebrafish with flia:eGFP. (A) qRT-PCR detected the expression of elnb in zebrafish at 72 hpf. WT, wild type; bves Mo, bves morphants. *p < 0.05. (B) qRT-PCR detected the expression of ELN in human tissue exapmles. CT, control, RVOT tissue of normal controls; TOF, tetralogy of fallot, hypertrophic RVOT tissue of patients. *p < 0.05. (C) bves morphants showed outflow tract defects at 72 hpf in Tg (flia:eGFP) zebrafish. The left column shows the outflow tract at the cardiac end-systolic stage, and the right column shows the end-diastolic stage. The words that marked by red color is the width of outflow tract. ca, caudal; cr, cranial; r, right; l, left. Scale bar = 15 μm. (D) Statistics about the width of outflow at the end-systolic stage in (C). Compared with the WT, the width of the outflow tract in bves knockdown mutants decreased by approximately 50% (WT, 9.5 μm; bves Mo, 5.0 μm, p < 0.01 compared with WT; bves Mo + bves mRNA, 7.5 μm, p < 0.01 compared with WT; p < 0.01 compared with bves Mo). OT, outflow tract; *Significance analysis with WT; ^#Significance analysis with bves Mo. **p < 0.01; ^##p < 0.01. n, number of samples. The error bar shows the mean and SD. bves Mo: bves morphants; WT: wild type; bves Mo + bves mRNA, coinject bves morpholino and bves mRNA.