Table 1.
Study | Eligibility | N Men | N Women |
---|---|---|---|
Epidemiological studies | |||
Osteoporotic Fractures in Men (MrOS) Study1,2 | Ambulatory community-dwelling men, aged ≥ 65 y | 5,835 | 0 |
Study of Osteoporotic Fractures (SOF)3,4 | Ambulatory community-dwelling women, aged ≥ 65 y | 0 | 1,246 |
Health, Aging and Body Composition Study (Health ABC)5 | Nondisabled black and white men and women aged 70–80 | 652 | 746 |
MrOS Sweden6 | Men aged ≥ 70 y in three Swedish communities | 2,876 | 0 |
Mr and MsOS Hong Kong7,8 | Men and women aged ≥ 65 y residing in Hong Kong | 2,000 | 2,000 |
Concord Health and Aging in Men Project (CHAMP)9 | Men aged ≥ 65 y living near Concord, Australia | 1,529 | 0 |
Cardiovascular Health Study10,11 | Age ≥65 y at original study enrollment | 638 | 871 |
Johnston County Arthritis Study12 | Rural white and black residents of Johnston County, North Carolina | 153 | 285 |
Epidemiological studies total | 13,683 | 5,148 | |
Clinical populations and randomized trials | |||
LIFE-Pilot Trial | Men and women aged 70–89 y | 72 | 187 |
VIVE2 Trial | Community-dwelling men and women ≥ 70 y | 80 | 64 |
TOM Trial | Community-dwelling men ≥ 65 y | 194 | — |
SECRET Trial | Men and women aged > 60 y with HFPEF | 16 | 71 |
PIE2 Trial | Men and women aged ≥ 60 y with HFPEF | 17 | 40 |
IDEA Trial | Men and women aged ≥ 60 y with closed hip fracture | 54 | 130 |
MACS Bone Strength Substudy (BOSS) | HIV-infected and HIV-uninfected men aged 50–79 y | 370 | — |
Women’s Interagency HIV Study | HIV-infected and HIV-uninfected women aged 30–55 | — | 187 |
Baltimore Hip Studies 4 | Community-dwelling women ≥ 65 y | — | 121 |
Baltimore Hip Studies 7 | Men and women aged ≥ 65 y and admitted for surgical repair of hip fracture | 54 | 71 |
Clinical populations and randomized trials total | 857 | 871 | |
Population-based studies | |||
Health and Retirement Survey (HRS) | Men and women aged 51+; our analyses limited to those ≥ 65 y | 3,170 | 4,200 |
National Health and Aging Trends Study (NHATS) | Nationally representative sample of Medicare beneficiaries, ≥ 65 y | 2,460 | 3,154 |
Population-based studies total | 5,630 | 7,354 |
Note: LIFE-Pilot, Lifestyle Intervention for Elders Pilot Study; MrOS Sweden, Osteoporotic Fractures in Men Study in Sweden; MrOS Hong Kong, Osteoporotic Fractures in Men Study in Hong Kong; MsOS Hong Kong, Osteoporotic Fractures in Women Study in Hong Kong; TOM Trial, Testosterone in Older Men with Mobility Limitation Trial; VIVE2 Trial, The Vitality, Independence, and Vigor in the Elderly 2 Study; SECRET Trial, Exercise Intolerance in Elderly Patients With HFpEF (Heart Failure With Preserved Ejection Fraction); PIE2 Trial, Pharmacologic Interventions in the Elderly Study 2; IDEA Trial, Intensive Diet and Exercise for Arthritis study.