Table 11.
Oral acute toxicity studies of chlorinated paraffins (CPs)
| CP category | CP specification | Species/strain | LD50 (g/kg bw) | Reference |
|---|---|---|---|---|
| SCCPs | C12, 60% chlorination | F344/N rat | > 13.6 | NTP (1986a); Bucher et al. (1987) |
| C12, 59% chlorination | Rat | > 21.5 | Diamond Shamrock Chem. Co (1975, unpublished study, as cited by Howard et al. (1975) and WHO/IPCS (1996) | |
| C12, 60% chlorination | B6C3F1 mouse | > 27.2 | NTP (1986a), Bucher et al. (1987) | |
|
Cereclor 50LV, C10–13, 50% chlorination |
Wistar rat | > 4 | Birtley et al. (1980) | |
| MCCPs | C14–17, 40–52% chlorination | Rat | > 15 | Kuhnert (1986a,b), Chater (1978), as cited by EU‐RAR (2011) |
|
Cereclor S52, C14–17, 52% chlorination |
Wistar rat | > 4 | Birtley et al. (1980) | |
| LCCPs | C23, 43% chlorination | F344/N rat | > 11.7 | NTP (1986b); Bucher et al. (1987) |
| C23, 43% chlorination | B6C3F1 mouse | > 23.4 | NTP (1986b); Bucher et al. (1987) | |
|
Cereclor 42, C20–30, 42% chlorination |
Wistar rat | > 4 | Birtley et al. (1980) |
LCCPs: long‐chain chlorinated paraffins; MCCPs: medium‐chain chlorinated paraffins; SCCPs: short‐chain chlorinated paraffins; LD50: lethal dose, median.