Table 24.
Benchmark dose modelling for the critical effects of medium‐chain chlorinated paraffins in experimental animals
| Critical effect | Model | BMDL10 | BMDU10 | Reference |
|---|---|---|---|---|
| (mg/kg bw per day) | ||||
| Increased absolute kidney weight – M + F rats |
Expon m3‐a Hill m3‐a |
81.5 | 364 | CXR (2005b) |
| Increased relative kidney weight – M + F rats |
Expon m3‐a Hill m3‐a |
67.9 | 182 | CXR (2005b) |
| Increased absolute kidney weight (left) – M + F rats |
Expon m3‐a Hill m3‐a |
101 | 418 | IRDC (1984c) |
| Increased relative kidney weight (left) – M + F rats |
Expon m3‐a Hill m3‐a |
36.4 | 224 | IRDC (1984c) |
| Critical effects | Model | BMDL 5 | BMDU 5 | Reference |
| (mg/kg bw per day) | ||||
| Combined incidence of subcutaneous haematoma/haemorrhage – rats | Model averaging | 48.5 | 63.8 | IRDC (1985) |
| Pup mortality – rats | Model averaging | 53.0 | 96.5 | IRDC (1985) |
bw: body weight; BMDL: benchmark dose lower confidence limit; BMDU: benchmark dose upper confidence limit; F: females; M: males.