Table 6.

In vivo chromosomal aberration results

Type of test	Experimental test system	Test substance	Exposure conditions	Result	WG considerations and conclusion	Reference
In vivo chromosomal aberration	BM cells of Chinese hamster (negative control: 8M + 8F, treated animals: 24M + 24F)	Triazine amine CGA 150 829 tech. (97.6%) Vehicle: 0.5% CMC = negative control	Preliminary tolerability test up to 5,000 mg/kg bw Gavage 0 & 3,200 mg/kg bw Sampling time: 16, 24 and 48 h after treatment	3,200 mg/kg bw = highest applicable dose No increase in the number of metaphases with specific aberrations	GLP compliant OECD 475 (1984) Slides of 5 males & 5 females selected for scoring 100 metaphases analysed/slide No information reported about the toxic effects observed in the preliminary tolerability test Major deviations from OECD TG 475 (2016) requirements Negative but no information on BM exposure	Report 871187

BM: bone marrow; M: male; F: Female; CMC: Carboxymethylcellulose.