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. 2020 Apr 29;18(4):e06088. doi: 10.2903/j.efsa.2020.6088

Table A.1.

CAG‐TCF and CAG‐TCP: Assessment of individual sources of uncertainty affecting the input data with respect to EKE Q1A and EKE Q1B

Assessment input Type of uncertainty Description of the uncertainty Range of multiplicative factor of MOET at 99.9th percentile of tier IIa Multiplicative factor identical for all populationsb Informative notes
Consumption data Excluded data Animal commodities and plant commodities not in the list of the 30 selected commodities and their processed derivatives were excluded −/● No

Note 1

Note 2

Note 3

Ambiguity The consumption data do not always discriminate between different commodities of a same group (e.g. tomatoes and cherry tomatoes are considered as tomatoes) Yes Note 4
Accuracy The accuracy of the reported amount of food consumed in surveys may be affected by methodological limitations or psychological factors Yes

Note 5

Note 6

Sampling variability Small population size (number of consumers in the 10 populations) may affect the reliability of risk estimates at 99.9th percentiles See confidence intervals of MOET estimates at 99.9th percentile of exposure distribution (Tables 1A and 2A) Note 7
Sampling bias Representativeness of the consumption data −/+ Yes Note 8
Use of fixed values One invariable recipe and conversion factor are used to convert the amount of food consumed into the respective amount of RPC Yes Note 9
Occurrence data Missing data Active substance/commodity combinations, for which occurrence data are missing and extrapolation from another commodity is not possible, were excluded Yes Note 10
Excluded data The contribution of metabolites and degradation products has not been considered −/● Yes Note 11
Ambiguity The occurrence data do not always discriminate between different commodities of a same group (e.g. tomatoes and cherry tomatoes are considered as tomatoes) Yes Note 4
Accuracy Laboratory analytical uncertainty Yes Note 12
Sampling variability A small number of occurrence data may affect the reliability of risk estimates at 99.9th percentile. This number varies from one pesticide/commodity combination to the other See confidence intervals of MOET estimates at 99.9th percentile of exposure distribution (Tables 1A and 2A) Note 7
Sampling bias Representativeness of the monitoring data ●/+ Yes Note 13
Extrapolation uncertainty Extrapolation of occurrence data between crops Yes Note 14
Extrapolation uncertainty Extrapolation of occurrence data between countries Yes Note 15
Assumption Assumption of the active substance present on the commodity in case of unspecific residue definition for monitoring

−/+ (CAG‐TCF)

−−/++ (CAG‐TCP)

Yes Note 16
Assumption Assumption of the authorisation status of all pesticide/commodity combinations −/● Yes Note 17
Assumption Assumption of the use frequency for authorised pesticide/commodity combinations −/+ Yes Note 18
Assumption Assumption on the residue level (½ LOQ) when an active substance is used, and its residues are below the LOQ Yes Note 31
Assumption Occurrence of residues in drinking water Yes Note 19
Processing factors Assumption Pesticide residues are transferred without any loss to processed commodities when processing factors are not available +/++ Yes Note 20
Ambiguity Application of processing factors, derived from a limited number of standardised studies, to the EFSA food classification and description system (FoodEx) Yes Note 21
Accuracy Laboratory analytical uncertainty Yes
Accuracy Calculation of processing factors is affected by residue levels below the LOQ Yes Note 22
Accuracy The value of processing factors used in the calculations is the median value of a limited number of independent trials Yes Note 23
Excluded data Some processing factors are not considered (e.g. peeling and washing of commodities with edible peel) ●/+ Yes Note 24
NOAELs Adequacy of the CAG Uncertainty on whether the CAG contains all the active substances causing the effect −/● Yes Note 25
Adequacy of the CAG Uncertainty on whether the CAG contains only the active substances causing the effect

● (CAG‐TCF)

●/+ (CAG‐TCP)

Yes Note 26
Accuracy Uncertainties affecting the characterisation of active substances included in the CAG (quality of data and NOAEL setting process)

−/● (CAG‐TCF)

−/+ (CAG‐TCP)

Yes Note 27
a

The range shown is the same for CAG‐TCF and CAG‐TCP unless otherwise indicated.

b

The experts considered that only the first source of uncertainty was expected, on its own, to have an impact varying between populations, as indicated in this column, but noted that more differences might be expected if multiple uncertainties were considered together.