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. 2020 Jun 17;18(6):e06123. doi: 10.2903/j.efsa.2020.6123
Commodity Region/indoora Residue levels observed in the supervised residue trials (mg/kg) Comments/Source Calculated MRL (mg/kg) HRb (mg/kg) STMRc (mg/kg)
Potatoes NEU 10 × < 0.02

5 trials on potato compliant with GAP and 5 overdosed trials on potato performed with 1.7N rate and one more application (United Kingdom, 2012), deemed acceptable since residues < LOQ. Residues of M320I04 < 0.01 mg/kg

MRLOECD = 0.02

Demonstrated stability: Yes

0.02* 0.02 0.02
SEU 10 × < 0.02

5 trials on potato compliant with GAP and 5 overdosed trials on potato performed with 1.7N rate (United Kingdom, 2012), deemed acceptable since residues < LOQ. Residues of M320I04 < 0.01 mg/kgMRLOECD = 0.02

Demonstrated stability: Yes

0.02* 0.02 0.02
Tomatoes SEU No data available
EU 0.03; 0.09; 0.10; 0.11; 0.14; 0.15; 0.19; 0.23; 0.38; 0.41

Trials on tomatoes compliant with GAP (United Kingdom, 2012). 4 selected values correspond to higher residue levels observed at a longer PHI. Residues of M320I04 < 0.01 mg/kg

Extrapolation from tomatoes to aubergines is applicable

MRLOECD = 0.68 Demonstrated stability: Yes

0.70 (tentative)d 0.41 0.15
Aubergines/eggplants SEU No data available
EU 0.03; 0.09; 0.10; 0.11; 0.14; 0.15; 0.19; 0.23; 0.38; 0.41

Trials on tomatoes compliant with GAP (United Kingdom, 2012). 4 selected values correspond to higher residue levels observed at a longer PHI. Residues of M320I04 < 0.01 mg/kg

Extrapolation from tomatoes to aubergines is applicable

MRLOECD = 0.68

Demonstrated stability: Yes

0.70 0.41 0.15
Sweet peppers/bell peppers SEU 0.05; 0.14; 0.15; 2 × 0.16; 0.18; 0.23; 0.50

Trials on sweet peppers compliant with GAP (Italy, 2011). Residues of M320I04 < 0.01 mg/kg

MRLOECD = 0.73

Demonstrated stability: Yes

0.80 (tentative)d 0.50 0.16
EU 0.10; 0.18; 0.21; 0.24; 0.28; 0.30; 0.34; 0.35; 0.41; 0.81

Trials on sweet peppers compliant with GAP (United Kingdom, 2012). 3 selected values correspond to higher residue levels observed at a longer PHI. Residues of M320I04 < 0.01 mg/kg

MRLOECD = 1.1

Demonstrated stability: Yes

1.50 (tentative)d 0.81 0.29

Cucumbers

Gherkins

Courgettes

EU < 0.02; 2 × 0.05; 0.06; 0.1; 0.15; 0.19; 0.2

Trials on cucumbers compliant with GAP (Italy, 2011). One selected value corresponds to higher residue at a longer PHI. Residues of M320I04 < 0.01 mg/kg

Extrapolation from cucumbers to gherkins and courgettes is acceptable

MRLOECD = 0.38

Demonstrated stability: Yes

0.40 (tentative for gherkins)d 0.20 0.08
Broccoli SEU 0.37; 0.54; 0.61; 3.82

Trials on broccoli compliant with GAP (Italy, 2011). Residues of M320I04 < 0.01 mg/kg

MRLOECD = 7.97

Demonstrated stability: Yes

Exceedances of the ARfD is observed for broccoli (unprocessed and processed)

10 3.82 0.58
SEU (fall‐back) 0.28; 0.41; 0.46; 2.87

Trial results scaled down with the fall‐back GAP (Italy, 2011; Sweden, 2019)

MRLOECD = 5.99

Demonstrated stability: Yes

Exceedance of the ARfD is still observed for processed broccoli. No safe fall‐back MRL could be calculated

8 2.87 0.44
Cauliflowers SEU < 0.02; 0.05; 0.07; 0.17

Trials on cauliflowers compliant with GAP (Italy, 2011). Last value corresponds to higher residue level observed at a longer PHI. Residues of M320I04 < 0.01 mg/kg

MRLOECD = 0.34

Demonstrated stability: Yes

0.50 (tentative)e 0.17 0.06
Brussels sprouts SEU 0.1; 0.12; 0.35; 0.39

Trials on Brussels sprouts compliant with GAP (Italy, 2011). All selected values correspond to higher residue levels observed at a longer PHI. Residues of M320I04 < 0.01 mg/kg

MRLOECD = 0.84

Demonstrated stability: Yes

1 0.39 0.24
Head cabbages SEU 2 × < 0.02; 0.05; 0.06

Trials on head cabbages compliant with GAP (Italy, 2011). Residues of M320I04 < 0.01 mg/kg

MRLOECD = 0.12

Demonstrated stability: Yes

0.15 0.06 0.04
Chinese cabbages/pe‐tsai SEU 0.13; 0.26; 1.33; 2.89

Trials on Chinese cabbage compliant with GAP (Italy, 2011). One selected value corresponds to higher residue level observed at a longer PHI. Residues of M320I04 ranged from < 0.01 mg/kg to 0.08 mg/kg

MRLOECD = 6.26

Demonstrated stability: Yes

8 (tentative)f 2.89 0.80
Kales SEU No data compliant with GAP available

Lamb's lettuces/corn salads

Escaroles/broad‐leaved endives

Cresses and other sprouts and shoots

Land cresses

Roman rocket/rucola

Red mustards

Baby leaf crops (including brassica species)

SEU 0.76; 2.68; 2.85; 2.98; 3.61; 4.98

Trials on lettuce compliant with GAP (only residue levels from open leaf varieties are reported) (Italy, 2011; Sweden, 2019). Residues of M320I04 ranged from < 0.01 mg/kg to 0.10 mg/kg

Extrapolation from open leaf varieties of lettuce to other salad plants is acceptable

MRLOECD = 8.93

Demonstrated stability: Yes

Exceedances of the ARfD is observed for escaroles/broad‐leaved endives (unprocessed and processed). No fall‐back MRL could be calculated for this crop

9 (tentative)f 4.98 2.92

Lamb's lettuces/corn salads

Cresses and other sprouts and shoots

Land cresses

Roman rocket/rucola

Red mustards

Baby leaf crops (including brassica species)

EU 4.7; 5; 5.5; 6.4

Trials on lettuce compliant with GAP (only residue levels from open leaf varieties are reported) (Italy, 2011; Sweden, 2019). Residues of M320I04 ranged from 0.01 mg/kg to 0.09 mg/kg

Extrapolation from open leaf varieties of lettuce to other salad plants is acceptable

MRLOECD = 16.2

Demonstrated stability: Yes

20 (tentative)f 6.40 5.25
Lettuces SEU 2.31; 3.44; 3.58; 3.62; 3.63; 5.34; 6.49; 7.11

Trials on lettuce compliant with GAP (Italy, 2011). All selected values correspond to higher values observed at a shorter PHI. Residues of M320I04 ranged from < 0.01 mg/kg to 0.03 mg/kg

Extrapolation from lettuce (open leaf varieties) to other salad plants is acceptable

MRLOECD = 13.32

Demonstrated stability: Yes

Exceedance of the ARfD is observed for lettuces

15 (tentative)f 7.11 3.63
SEU (fall‐back) 0.15; 0.94; 1.12; 1.17; 1.52; 1.61; 2.39; 3.14

Trials on lettuce compliant with fall‐back GAP (Italy, 2011; Sweden, 2019). Residues of M320I04 ranged from < 0.01 mg/kg to 0.07 mg/kg

MRLOECD = 5.17

Demonstrated stability: Yes

6 (tentative)f 3.14 1.35
EU 2; 2.4; 3.1; 4.4; 4.7; 5; 5.5; 6.4

Trials on lettuce compliant with GAP (Italy, 2011). One selected value corresponds to higher value observed at a longer PHI. Residues of M320I04 ranged from < 0.01 mg/kg to 0.09 mg/kg

Extrapolation from lettuce (open leaf varieties) to other salad plants is acceptable

MRLOECD = 12.56

Demonstrated stability: Yes

Exceedance of the ARfD is observed for lettuces. No fall‐back MRL could be calculated

15 (tentative)f 6.40 4.55

GAP: Good Agricultural Practice; OECD: Organisation for Economic Co‐operation and Development; MRL: maximum residue level; PHI: preharvest interval.

*

Indicates that the MRL is proposed at the limit of quantification.

a

NEU: Outdoor trials conducted in northern Europe, SEU: Outdoor trials conducted in southern Europe, Indoor: indoor EU trials or Country code: if non‐EU trials.

b

Highest residue. The highest residue for risk assessment (RA) refers to the whole commodity and not to the edible portion.

c

Supervised trials median residue. The median residue for risk assessment (RA) refers to the whole commodity and not to the edible portion.

d

MRL is tentative considering that residue levels of metaflumizone in raw tomato and residue levels of metabolite M320I04 in processed tomato are significant, while the toxicological relevance of this metabolite is not fully elucidated. Considering that processing of tomato, sweet pepper and gherkin is comparable, MRL is tentative also for these commodities.

e

MRL is tentative because additional trials compliant with GAP are needed.

f

MRL is tentative considering that residue levels of metabolite M320I04 are measured in the GAP‐compliant field trials on lettuce and Chinese cabbage, while the toxicological relevance of this metabolite is not fully elucidated.