Table 2.

Univariate and multivariate Cox proportional hazards regression analyses in 17845 patients.

CSS	Univariate cox analysis			Multivariate cox analysis
	HR	SE	P	HR	SE	P
Age	1.004	0.0008	5.54e-08∗∗	1.004	0.0008	1.74e-06∗∗∗
Sex
Male	Reference			Reference
Female	0.976	0.0228	0.290	0.9646	0.0237	1.12872
Histology
SCN	Reference			Reference
ANA	0.915	0.0197	6.27e-06∗∗∗	1.001	0.0209	0.99621
EN	1.123	0.0506	0.022	0.9837	0.0515	0.75023
CMSN	1.004	0.0436	0.919	1.014	0.0447	0.75682
CEN	1.106	0.0934	0.280	1.041	0.0939	0.67022
Grade
Grade I	Reference			Reference
Grade II	1.429	0.0507	<0.05	1.169	0.0097	0.00213
Grades III-IV	1.689	0.0501	<0.05	1.241	0.0508	2.12e-05∗∗∗
Unknown	1.538	0.0538	<0.05	1.143	0.0543	0.01376
T stage
T1	Reference			Reference
T2	0.956	0.0362	0.209	0.976	0.0365	0.50689
T3	1.203	0.0244	<0.05	1.104	0.0253	9.41e-05∗∗∗
T4	1.613	0.0295	<0.05	1.221	0.0305	5.76e-11∗∗∗
TX	1.755	0.0291	<0.05	1.244	0.0308	1.42e-12∗∗∗
N stage
N0	Reference			Reference
N1	1.899	0.0431	<0.05	1.667	0.0441	<2e-16
N2	2.228	0.0537	<0.05	2.056	0.0552	<2e-16
N3	2.714	0.0644	<0.05	2.381	0.0662	<2e-16
NX	2.398	0.0293	<0.05	1.420	0.0577	1.25e-09∗∗∗
M stage
M0	Reference			Reference
M1	1.702	0.0187	<0.05	1.306	0.0212	<2e-16
MX	1.677	0.0878	3.99e-09	1.178	0.0911	0.0717
Tumor size	1.033	0.0017	<0.05	1.015	0.0023	7.81e-11∗∗∗
Lymph node examined
≤2	Reference			Reference
>2	0.580	0.0223	<0.05	0.9539	0.0657	0.47227
Surgery statue
No surgery	Reference			Reference
Local tumor ED	0.272	0.0887	<0.05	0.3537	0.0907	<2e-16
Esophagectomy	0.494	0.0395	<0.05	0.67	0.0636	2.95e-10∗∗∗
Esophagectomy LG	0.555	0.0240	<0.05	0.7234	0.0576	1.84e-08∗∗∗