Table 1.
Cytotoxic effects of ruthenium (II) complexes on human cancer and normal cell linesa.
| Complexes | IC50 (μM) | |||||
|---|---|---|---|---|---|---|
| A549 | HeLa | MCF-7 | HepG2 | BEAS-2B | SI | |
| Ru(dip)2Cl2 | 138.4 ± 6.7 | 115.6 ± 6.8 | 134.9 ± 7.9 | 108.5 ± 5.4 | — | — |
| Ru(dmp)2Cl2 | >200 | >200 | >200 | 169.3 ± 6.2 | — | — |
| SA | >200 | >200 | >200 | >200 | — | — |
| Ru-1 | 11.3 ± 1.1b | 20.1 ± 1.3b | 29.5 ± 2.2b | 15.4 ± 1.0 | 54.3 ± 3.4b | 4.9 |
| Ru-2 | 30.1 ± 1.2b | 32.5 ± 2.4b | 45.7 ± 3.7b | 26.4 ± 2.1 | 48.1 ± 3.7b | 1.6 |
| Cisplatin | 27.2 ± 1.4 | 18.3 ± 1.2 | 16.2 ± 2.0 | 30.2 ± 2.0 | 21.4 ± 1.5 | 0.8 |
aCells were treated with various concentrations of complexes for 48 h. SI (selectivity index) = IC50 (BEAS-2B)/IC50 (A549).bp < 0.01 represents significant differences compared with BEAS-2B.