TABLE 3.

White matter connectivity (fixel‐based morphometry) across FTO genotype groups

Seed	Contrast	Measure	Region	Cluster size	Peak t value	Peak p value
Right Crus I	CC > TT	FDC	Middle cerebellar peduncle	6	6.19	0.042
		FC	Left corticospinal tract to middle cerebellar peduncle	1954	4.33	0.005
	CC > CT	FDC	Left corticospinal tract to middle cerebellar peduncle	21	4.79	0.038
		FC	Bilateral corticospinal tract to middle cerebellar peduncle	2430	4.08	0.003
Left Crus I	CC > TT	FDC	Middle cerebellar peduncle	22	6.32	0.039
		FC	Left corticospinal tract to middle cerebellar peduncle	1836	4.75	0.005
	CC > CT	FDC	Left corticospinal tract to middle cerebellar peduncle	36	4.79	0.038
		FC	Bilateral corticospinal tract to middle cerebellar peduncle	2475	4.09	0.002
Right Crus II	CC > TT	FDC	Middle cerebellar peduncle	8	6.32	0.042
		FC	Left corticospinal tract to middle cerebellar peduncle	1999	4.74	0.004
	CC > CT	FDC	Left corticospinal tract to middle cerebellar peduncle	18	4.80	0.039
		FC	Bilateral corticospinal tract to middle cerebellar peduncle	2404	4.10	0.003
Left Crus II	CC > TT	FDC	Middle cerebellar peduncle	23	6.34	0.037
		FC	Left corticospinal tract to middle cerebellar peduncle	1886	4.75	0.005
	CC > CT	FDC	Bilateral corticospinal tract to middle cerebellar peduncle	31	5.10	0.036
		FC	Bilateral corticospinal tract to middle cerebellar peduncle	2497	4.07	0.003
Anterior middle temporal gyrus	CC > TT	FC	Right uncinate fasciculus	152	4.84	0.019
	CC > CT	FC	Right inferior longitudinal fasciculus	28	3.68	0.040
Right temporal fusiform cortex	CC > TT	FC	Right inferior longitudinal fasciculus	47	4.55	0.031
		FDC	Right inferior longitudinal fasciculus	15	5.02	0.037

Note: All fixels are significant at family‐wise error (FWE) p < 0.05.

Abbreviations: FD, fibre density; FDC, fibre density and cross section.