Table 2.
Patient ID | BALF mNGS result | SMRN | Blood mNGS result | SMRN | Clinical diagnosis | Changes in treatment |
---|---|---|---|---|---|---|
03 | Stenotrophomonas maltophilia | 14 | — | — | HAP | Discontinuation of Tigecycline |
Candida albicans | 6 | |||||
05 | Candida tropicalis | 5 | — | — | HAP | No change |
06 | — | — | Pneumocystis jirovecii | 40 | PJP | No change |
15 | — | — | — | — | CAP | Discontinuation of Amphotericin B |
30 | Candida tropicalis | 49 | — | — | HAP | No change |
Candida glabrata | 4 | |||||
33 | Pneumocystis jirovecii | 123887 | Pneumocystis jirovecii | 417 | PJP Bacterial infection |
No change |
Acinetobacter baumannii | 553 | |||||
Escherichia coli | 27 | |||||
36 | — | — | — | CAP | No change | |
37 | — | — | Acinetobacter baumannii | 6 | CAP | No change |
38 | — | — | — | — | HAP | No change |
39 | — | — | — | — | Aspiration pneumonia | No change |
Abbreviations: mNGS, metagenomic next-generation sequencing; SMRN, number of reads stringently mapped to pathogen species; PJP, Pneumocystis jirovecii Pneumonia; CAP, community-acquired pneumonia; HAP, hospital-acquired pneumonia.