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Proposed SAM-dependent conversion of estrogens into androgens by EMT. The EmtAB components transfer the methyl group from SAM to cob(I)alamin, and from the methylcob(III)alamin formed to estradiol. The exergonic first methyl transfer drives the endergonic second methyl transfer forward. The accidentally oxidized inactive cob(II)alamin is regenerated by electron transfer from an unknown electron donor probably mediated by ATP-dependent RACE, and the EmtCD components.
