Table 1.

Frequencies of three Roma prevalent hearing loss variants in gnomAD

gnomAD allele frequencies	MANBA c.2158-2A>G	GJB2 c.71G>A, p.W24*	MARVELD2 c.1331+2T>C
	rs772852668	rs104894396	rs772048719
all	0.0024%	0.052%	0.0040%
South Asian population	0%	0.44%	0.020%
genotypes - het: wt	0: 15303	134: 15174	6: 15302
European Non-Finish population	0.0018%	0.0063%	0.0026%
genotypes - hom:het:wt	0: 2: 56692	1: 6: 63872	0: 3: 56781
Latino population	0.012%	0.0028%	0%
Allele frequencies detected in this report
CZ genotypes - het: wt	1.89% 5: 127 (3.79%)	Not tested	Not tested
SK genotypes - het: wt	1.88% 8: 205 (3.76%)	Not tested	Not tested

Legend – gnomAD [39] allele frequencies and genotypes for prevalent Roma variants in MANBA, GJB2 and MARVELD2 are shown. All populations, in which the frequency was detected, are shown except for the c.71G>A (p.W24*) where one more frequency is listed (OTH - other populations, 4 heterozygotes were detected). The frequency and numbers of individual genotypes are listed for the complex overview

CZ - Czech Roma population, SK - Slovak Roma population, Het - heterozygous for pathogenic allele, hom - homozygous for pathogenic allele, wt - wildtype, both alleles are reference alleles, frequencies are in bold