Fig. 1.

ZIKV infection induces IL-22 expression. a Transcript levels of IL-22 were measured in various organs of ZIKV-infected IFNAR^-/- mice. b γδ17 and γδ22 T cells were analyzed in the brain and spleen of ZIKV-infected IFNAR^-/- mice. c IL-22 transcript levels were measured in the brain and spleen of ZIKV-infected neonatal B6 mice. d γδ17 and γδ22 T cells were analyzed in the brain and spleen of ZIKV-infected neonatal B6 mice at 13 dpi. e IL-22 protein levels were quantified in the brain and spleen at 13 dpi. All experiments were repeated twice independently. A two-tailed Student’s t test was used to compare the two groups. One-way ANOVA was used to compare more than two groups. *p < 0.05, **p < 0.01, and ***p < 0.001