Table I.
Inhibition of EMT by miRNAs.
| miRNA | Cancer type | Molecular targets | (Refs.) |
|---|---|---|---|
| miR-125b-5p | Hepatocellular carcinoma | STAT3 | (62) |
| miR-200 family | Gastric adenocarcinoma | ZEB1/2, β-catenin | (73,74) |
| Hepatocellular carcinoma | β-catenin | (76) | |
| Colonic adenocarcinoma | ZEB1/2 | (75) | |
| miR-122 | Hepatocellular carcinoma | Wnt1, Snail1/2 | (83,96) |
| miR-3127-5p | Non-small-cell lung cancer | FZD4 | (100) |
| miR-136 | Melanoma | PMEL | (122) |
| miR-708 | Melanoma | LEF1 | (84) |
| miR-203 | Breast cancer | DKK1 | (178) |
| miR-490-3p | Colorectal cancer | FRAT1 | (103) |
| miR-34b/c | Prostate cancer | β-catenin | (93) |
| miR-148a | Hepatocellular carcinoma | Wnt1 | (97) |
| Pancreatic cancer | Wnt10b | (98) | |
| miR-34a | Prostate cancer | LEF1 | (85) |
| miR-101 | Colon cancer | EZH2 | (179) |
| miR-22 | Melanoma | FMNL2 | (121) |
| miR-33b | Lung adenocarcinoma | ZEB1 | (80) |
| miR-145 | Lung cancer | Oct4 | (92) |
| miR-194 | Hepatocellular carcinoma | PRC1 | (118) |
| miR-300 | Pancreatic cancer | CUL4B | (110) |
| miR-338 | Gastric cancer | EphA2 | (114) |
| miR-495 | Non-small-cell lung cancer | TCF4 | (88) |
| miR-506 | Nasopharyngeal carcinoma | LHX2 | (116) |
| miR-3619-5p | Bladder carcinoma | β-catenin, CDK2, p21 | (94) |
| miR-15a-3p | Prostate cancer | SLC39A7 | (104) |
| miR-29c | Colorectal carcinoma | GNA13, PTP4A | (123) |
| miR-33a | Pancreatic cancer | β-catenin | (95) |
| miR-302b | Gastric cancer | EphA2 | (113) |
| miR-340 | Ovarian cancer | FHL2 | (180) |
| miR-375 | Gastric cancer | YWHAZ | (120) |
| miR-377 | Ovarian cancer | CUL4A | (111) |
| miR-378 | Colon cancer | SDAD1 | (60) |
| miR-498 | Liver cancer | ZEB2 | (81) |
| miR-504 | Glioblastoma | FZD7 | (101) |
| miR-516a-3p | Breast cancer | Pygo2 | (87) |
| miR-519d | Gastric cancer | Twist1 | (82) |
| miR-770 | Non-small-cell lung cancer | JMJD6 | (124) |
| miR-876-5p | Gastric cancer | Wnt5A and MITF | (89) |
| miR-33a-5p | Hepatocellular carcinoma | PNMA1 | (181) |
| miR-383 | Pancreatic carcinoma | ROBO3 | (182) |
| miR-371-5p | Colorectal cancer | SOX2 | (183) |
| miR-370-3p | Bladder cancer | Wnt7a | (99) |
STAT3, signal transducer and activator of transcription 3; ZEB, zinc finger E-box-binding homeobox; FZD, Frizzled; PMEL, Premelanosome Protein; LEF1, lymphoid enhancer factor 1; DKK1, Dickkopf 1; FRAT1, frequently rearranged in advanced T-cell lymphomas 1; EZH2, enhancer of zeste homolog 2; FMNL2, formin like 2; Oct4, octamer-binding protein 4; PRC1, protein regulator of cytokinesis 1; CUL4B, cullin 4B; EphA2, EPH receptor A2; TCF4, T-cell factor 4; LHX2, LIM homeobox 2; CDK2, cyclin-dependent kinase 2; PTP4A, protein tyrosine phosphatase 4A2; GNA13, G protein subunit alpha 13; FHL2, four and a half LIM domains 2; CUL4A, Cullin 4A; SDAD1, SDA1 Domain Containing 1; Pygo2, Pygopus2; JMJD6, Jumonji Domain Containing 6; MITF, melanogenesis-associated transcription factor; PNMA1, paraneoplastic ma sntigen 1; ROBO3, roundabout guidance receptor 3; SOX2, SRY-box transcription factor 2.