Figure 6.
Expression of CLDN3, and N-glycan-related genes (MGAT5, ST6GAL1, and B3GNT8) in samples from patients with colorectal cancer (CRC). Box graphs represents absolute values of gene expression from tumors (n=644) and normal tissue samples (n=51) accessed in The Cancer Genome Atlas (TCGA) database. (A) Colorectal cancer consensus molecular subtypes (CMS). CMS1 n=90; CMS2 n=242; CMS3 n=78; CMS4 n=165; and (B) colorectal cancer disease stages (i, ii, iii, iv). Only significant differences are highlighted. The symbols correspond to the Dunn's rank sum test P-values adjusted with Hochberg's multiple comparisons correction *Padj <0.05; **Padj <0.01; ***Padj <0.001; ****Padj <0.0001. CLDN3, gene encoding claudin-3; MGAT5, α-mannoside β-1,6-N-acetylglucosaminyltransferase; ST6GAL1, ST6 β-galactoside α-2,6-sialyltransferase; B3GNT8, β-1,3-N-αcetylglucosaminyltransferase 8.