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. 2020 Aug 11;44(4):1561–1573. doi: 10.3892/or.2020.7730

Figure 1.

Figure 1.

Effect of pulsed kevetrin on AML cell line viability, cell cycle progression and apoptosis induction. Viability of (A) MOLM-13 and (B) KASUMI-1 cell lines treated with different concentrations of kevetrin (85, 170 and 340 µM) for up to 3 pulsations. (C and D) Quantification of Annexin V+ cells in MOLM-13 and KASUMI-1 models before and after treatment with 85, 170 and 340 µM kevetrin for 6 and 6+66 h wo (×3). Cell cycle analysis of MOLM-13 and KASUMI-1 cells after (E) 6 h and (F) 6+66 h wo (×3) kevetrin treatment. Values represent the mean ± standard deviation of 3 biological replicates (*P<0.05, **P<0.01, ***P<0.001). AML, acute myeloid leukemia; wo, wash-out; CTRL, control.