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. 2020 Aug 11;44(4):1561–1573. doi: 10.3892/or.2020.7730

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Copyright: © Napolitano et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Transcriptional changes induced by a 48-h exposure to 340 µM kevetrin. (A) Number of genes upregulated and downregulated in MOLM-13 and KASUMI-1 cells. (B) Fold-change of expression for leukemia-related genes from the common core transcriptional program in the two lines (ratio between kevetrin-treated and control cells). (C) Downregulation of glycolysis, DNA repair, UPR and MYC target signatures identified by gene set enrichment analysis. (D) Enrichment of a p53-related transcriptional signature in treated MOLM-13 and KASUMI-1 cells. (E) p53 target genes were upregulated in both cell lines following exposure to kevetrin (340 µM for 48 h). NES, normalized enrichment score; UPR, unfolded protein response.