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. 2020 Jul 31;44(4):1605–1615. doi: 10.3892/or.2020.7708

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Copyright: © Ren et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — RES sensitizes AGS cells to DDP by inducing cell apoptosis. (A) Cell apoptosis was detected after RES (20 µM) and DDP (1 µg/ml) cotreatment for 48 and 72 h through FITC-Annexin V/PI assays and flow cytometry. (B and C) Histograms revealing the percentage of apoptotic cells. (D and E) The expression levels of Bax, Bcl-2 and PARP were detected by western blotting. The results are presented as the mean ± SD (n=3). *P<0.05, **P<0.01 and ***P<0.001. RES, resveratrol; DDP, cisplatin; PARP, poly-ADP-ribose polymerase; CTRL, control; COM, combination treatment.