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. 2020 Jul 31;44(4):1605–1615. doi: 10.3892/or.2020.7708

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Copyright: © Ren et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — RES sensitizes AGS cells to DDP by inducing G2/M cell cycle arrest. (A) PI staining and flow cytometry were performed to determine cell cycle progression after RES (20 µM) and DDP (1 µg/ml) cotreatment for 48 and 72 h. (B and C) The percentage of cells in the G2/M phase was examined. (D-F) After RES (20 µM) and DDP (1 µg/ml) combination treatment for 48 h, the protein levels of cyclin B1, p-CDK1 (Tyr15), CDK1, Cdc25C, p21^Waf1/Cip1 and p27^Kip1 were detected by western blotting. All data are presented as the mean ± SD (n=3). *P<0.05, **P<0.01 and ***P<0.001. RES, resveratrol; DDP, cisplatin; p-CDK1, phosphorylated cyclin-dependent kinase 1; CTRL, control; COM, combination treatment.