Table 2.
Multivariate COX hazards regression for OS and LCSS in IIIA/N2 NSCLC patients based on prognostic factors
| Variables | OS | LCSS | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR(95% Cl) | P | HR(95% Cl) | P | HR(95% Cl) | P | HR(95% Cl) | P | |
| Gender | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| Female | Reference | Reference | Reference | Reference | ||||
| Male | 0.799(0.772,0.828) | <0.001 | 0.823(0.794,0.853) | <0.001 | 0.823(0.792,0.855) | <0.001 | 0.845(0.813,0.879) | <0.001 |
| Age | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| < 75 | Reference | Reference | Reference | Reference | ||||
| > =75 | 1.645(1.582,1.710) | <0.001 | 1.364(1.310,1.421) | <0.001 | 1.590(1.524,1.659) | <0.001 | 1.334(1.276,1.395) | <0.001 |
| Histology | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| Adenocarcinoma | Reference | Reference | Reference | Reference | ||||
| Squamous | 1.429(1.372,1.489) | <0.001 | 1.228(1.177,1.281) | <0.001 | 1.388(1.328,1.451) | <0.001 | 1.193(1.139,1.250) | <0.001 |
| Adenosquamous | 1.159(1.018,1.319) | 0.026 | 1.114(0.977,1.269) | 0.106 | 1.138(0.988,1.312) | 0.073 | 1.087(0.943,1.254) | 0.25 |
| Large cell | 1.248(1.125,1.384) | <0.001 | 1.159(1.041,1.292) | 0.007 | 1.303(1.167,1.456) | <0.001 | 1.209(1.077,1.357) | 0.001 |
| OTHER | 1.395(1.328,1.464) | <0.001 | 1.187(1.128,1.250) | <0.001 | 1.411(1.339,1.488) | <0.001 | 1.196(1.132,1.265) | <0.001 |
| Chemotherapy | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| No | Reference | Reference | Reference | Reference | ||||
| Yes | 0.556(0.536,0.577) | <0.001 | 0.635(0.610,0.662) | <0.001 | 0.586(0.563,0.610) | <0.001 | 0.665(0.636,0.695) | <0.001 |
| Tumor Size | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| ≤ 3 | Reference | Reference | Reference | Reference | ||||
| 3--5 | 1.275(1.231,1.320) | <0.001 | 1.221(1.178,1.266) | <0.001 | 1.311(1.261,1.362) | <0.001 | 1.258(1.209,1.308) | <0.001 |
| Grade | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| Grade I | Reference | Reference | Reference | Reference | ||||
| Grade II | 1.128(1.015,1.253) | 0.025 | 1.134(1.020,1.260) | 0.02 | 1.147(1.021,1.289) | 0.021 | 1.154(1.027,1.297) | 0.016 |
| Grade III | 1.34(1.210,1.485) | <0.001 | 1.334(1.203,1.480) | <0.001 | 1.399(1.249,1.567) | <0.001 | 1.386(1.235,1.554) | <0.001 |
| Grade IV | 1.593(1.351,1.880) | <0.001 | 1.512(1.275,1.794) | <0.001 | 1.604(1.336,1.926) | <0.001 | 1.495(1.237,1.806) | <0.001 |
| unknow | 1.569(1.417,1.737) | <0.001 | 1.496(1.348,1.660) | <0.001 | 1.627(1.453,1.821) | <0.001 | 1.544(1.377,1.732) | <0.001 |
| Radiation with surgery | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| Only surgery | Reference | Reference | Reference | Reference | ||||
| Preoperative radiotherapy | 0.477(0.429,0.531) | <0.001 | 0.589(0.529,0.657) | <0.001 | 0.507(0.452,0.568) | <0.001 | 0.606(0.539,0.681) | <0.001 |
| postoperative radiotherapy | 0.632(0.602,0.662) | <0.001 | 0.775(0.737,0.816) | <0.001 | 0.645(0.612,0.679) | <0.001 | 0.772(0.731,0.816) | <0.001 |
| Raiotherapy both before and after sugery | 0.593(0.466,0.755) | <0.001 | 0.752(0.590,0.957) | 0.021 | 0.56(0.426,0.736) | <0.001 | 0.687(0.522,0.904) | 0.007 |
| No surgery or radiation | 1.052(1.010,1.095) | 0.015 | 1.035(0.991,1.082) | 0.121 | 1.057(1.011,1.104) | 0.014 | 1.023(0.975,1.073) | 0.356 |
| Primary Site | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| Upper lobe | Reference | Reference | Reference | Reference | ||||
| Middle lobe | 1.026(0.943,1.116) | 0.557 | 1.009(0.926,1.099) | 0.833 | 1.053(0.962,1.153) | 0.26 | 1.026(0.935,1.124) | 0.592 |
| Lower lobe | 1.103(1.059,1.149) | <0.001 | 1.08(1.037,1.125) | <0.001 | 1.102(1.054,1.151) | <0.001 | 1.078(1.032,1.127) | 0.001 |
| NOS | 1.303(1.172,1.449) | <0.001 | 1.314(1.172,1.474) | <0.001 | 1.29(1.148,1.449) | <0.001 | 1.311(1.157,1.486) | <0.001 |
| Overlapping lesion | 0.985(0.808,1.199) | 0.877 | 1.024(0.840,1.248) | 0.814 | 0.922(0.738,1.153) | 0.478 | 0.945(0.756,1.182) | 0.62 |
| Main bronchus | 1.252(1.136,1.379) | <0.001 | 1.128(1.023,1.245) | 0.016 | 1.302(1.174,1.444) | <0.001 | 1.171(1.054,1.301) | 0.003 |
| Laterality | 0.001 | <0.001 | <0.001 | <0.001 | ||||
| Right-origin of primary | Reference | Reference | Reference | Reference | ||||
| Left-origin of primary | 0.932(0.899,0.966) | <0.001 | 0.926(0.893,0.961) | <0.001 | 0.907(0.872,0.944) | <0.001 | 0.904(0.868,0.941) | <0.001 |
| Paired sit | 0.836(0.633,1.104) | 0.206 | 0.717(0.532,0.966) | 0.029 | 0.809(0.595,1.100) | 0.177 | 0.694(0.500,0.964) | 0.029 |
| Only one side - side unspecified | 1.556(0.861,2.810) | 0.143 | 1.339(0.737,2.430) | 0.338 | 1.14(0.543,2.391) | 0.73 | 0.991(0.470,2.090) | 0.982 |
| Not a paired site | 1.266(0.408,3.927) | 0.683 | 1.371(0.438,4.288) | 0.587 | 1.532(0.494,4.752) | 0.46 | 1.647(0.526,5.158) | 0.392 |
Abbreviations: NSCLC Non-small cell lung cancer, IIIA/N2 Stage IIIA pathologic N2, OS Overall survival, LCSS Lung cancer-specific survival, HRs Hazard ratios