Table II.

Differences between melanoma risk factors in female and male patients (sex- and age-matched dataset, n=278).

							Female						Male
	Female		Male				With metastasis		Without metastasis				With metastasis		Without metastasis
Risk factor	N	%	N	%	OR (95% CI)	P-valuea	N	%	N	%	OR (95% CI)	P-valuea	N	%	N	%	OR (95% CI)	P-valuea
Tumor localization
Head and neck	40	12.2	29	12.7		<0.001	15	9.1	25	15.3		0.401	13	11.4	16	14.0		0.902
Limbs	155	47.3	62	27.2			80	48.8	75	45.7			33	29.0	29	25.5
Trunk	113	34.4	119	52.2			58	35.4	55	33.5			59	51.7	60	52.6
Hands and feetd	20	6.1	18	7.9			11	6.7	9	5.5			9	7.9	9	7.9
Totale	328	100.0	228	100.0			164	100.0	164	100.0			114	100.0	114	100.0
CM subtype
Superficial spreading melanoma	15	16.3	8	15.4		0.693c	10	21.7	5	10.9		0.191c	5	19.2	3	11.5		0.465c
Nodular melanoma	72	78.3	43	82.7			35	76.1	37	80.4			20	76.9	23	88.5
Lentigo malignant melanoma	5	5.4	1	1.9			1	2.2	4	8.7			1	3.9	0	0.0
Totale	92	100.0	52	100.0			46	100.0	46	100.0			26	100.0	26	100.0
Breslow thickness, mm
Mean ± SD	4.95±6.33	4.11±4.31	0.479b	5.66±6.86	4.24±5.70	0.013b	4.53±4.93	3.70±3.56	0.435b
Median	3.0	3.0		4.0	2.0		3.0	3.0
≤1.0	64	24.8	45	26.2		0.325	32	24.8	32	24.8		0.001	22	25.6	23	26.7		0.907
1.0-2.0	45	17.5	27	15.7			11	8.5	34	26.4			12	14.0	15	17.5
2.0-4.0	56	21.7	49	28.5			30	23.3	26	20.1			25	29.1	24	27.9
>4.0	93	36.0	51	29.6			56	43.4	37	28.7			27	31.3	24	27.9
Totale	258	100.0	172	100.0			129	100.0	129	100.0			86	100.0	86	100.0
Ulceration
Absent	78	40.2	64	50.0	Ref		31	32.0	47	48.5	Ref		30	46.9	34	53.1	Ref
Present	116	59.8	64	50.0	0.67 (0.43-1.05)	0.106	66	68.0	50	51.5	2.00 (1.12-3.59)	0.028	34	53.1	30	46.9	1.28 (0.64-2.57)	0.596
Totale	194	100.0	128	100.0			97	100.0	97	100.0			64	100.0	64	100.0
Pigment
Present	237	90.5	167	90.8	Ref		112	85.5	125	95.4	Ref		83	90.2	84	91.3	Ref
Absent	25	9.5	17	9.2	0.97 (0.51-1.84)	1.000c	19	14.5	6	4.6	3.53 (1.36-9.16)	0.010c	9	9.8	8	8.7	1.14 (0.42-3.09)	1.000c
Totale	262	100.0	184	100.0			131	100.0	131	100.0			92	100.0	92	100.0
Predominant cell type in the lesion
Epithelial	130	63.7	109	70.8		0.236	64	62.7	66	64.7		0.174	57	74.0	52	67.5		0.518
Spindle	31	15.2	23	14.9			12	11.8	19	18.6			9	11.7	14	18.2
Mixed	43	21.1	22	14.3			26	25.5	17	16.7			11	14.3	11	14.3
Totale	204	100.0	154	100.0			102	100.0	102	100.0			77	100.0	77	100.0
BMI
Mean ± SD	28.5±6.27	28.3±4.84	0.810b	28.9±6.10	28.0±6.44	0.224b	28.2±4.63	28.4±5.09	0.598b
Median	27.4	27.9		27.9	27.1		26.9	27.9
18.01-25.00	56	31.5	28	23.7	0.054		25	28.1	31	34.8		0.593	15	25.4	13	22.0		0.718
25.01-30.00	57	32.0	54	45.8			29	32.6	28	31.5			28	47.5	26	44.1
>30.01	65	36.5	36	30.5			35	39.3	30	33.7			16	27.1	20	33.9
Totale	178	100.0	118	100.0			89	100.0	89	100.0			59	100.0	59	100.0

^aP-values were obtained by the χ² test unless indicated otherwise.

^bMann-Whitney test.

^cFisher's exact test.

^dAcral lentiginous melanomas were excluded before analysis.

^eThe number of matched cases in each group; if there was missing information for an individual in one of the groups, the corresponding case-control pair was excluded from the analysis. OR and 95% CI are presented for predictors with two categories.