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. 2020 Aug 20;4(16):3927–3942. doi: 10.1182/bloodadvances.2019001032

Figure 2.

Figure 2.

Treg homeostasis in recipients without aGVHD after HCT. Shown are results for donor/recipients couples without aGVHD from cohort 1. (A) Frequency of FOXP3+ cells within the CD4+ population in donors (D) and recipients (R) at day 90 post-HCT. (B) Frequencies of Ki-67+, within the CD4+ FOXP3+ Treg population, in donors (D) and recipients (R) at day 90 post-HCT. (C) Frequency of proliferating (Ki-67+) cells within the CD4+FOXP3+ Treg and CD4+FOXP3− Tconv populations in donors (D) and recipients (R) (left panel) and ratios of proliferating (Ki-67+) Treg/Tconv in donors (D) and recipients (R) at day 90 post-HCT (right panel). (D) Frequencies of CTLA4+, ICOS+, and PD1+ cells within the CD4+FOXP3+ Treg population in donors (D) and recipients (R) at day 90 post-HCT. Horizontal lines indicate the median. P values were calculated using a Wilcoxon matched-pairs Student t test or a Mann-Whitney U test. Differences are considered significant for P < .05.