Table 1.

Proposed response criteria for patient evaluation in BPDCN

BPDCN compartment of disease*	Evaluation method	Response criteria disease area	Year/reference	Notes
Cutaneous (skin)	mSWAT	CTCL	2011/51	mSWAT = modified severity weighted assessment tool
Blood/bone marrow	CBC; bone marrow aspiration/biopsy	AML	2003/52	BPDCN can transform to AML, so always confirm diagnosis with expert pathology team
Lymph node	PET/CT; CT	NHL	2014/53	Can also image other visceral/extramedullary sites

BPDCN response criteria based on Pemmaraju et al.⁴⁴ CR equals no detectable disease in all 3 compartments.

CBC, complete blood count; CT, computed tomography; CTCL, cutaneous T-cell lymphoma; NHL, non-Hodgkin lymphoma; PET, positron emission tomography.

^*CRc equals no detectable disease noted in nonskin organs, with gross decrease in cutaneous lesions; evidence of microscopic residual skin disease.