Table 4.
Association of baseline CKD awareness with incident ESKD, CHD, stroke, and death, using Cox proportional hazard models and accounting for the competing risk of death (N = 6,529).
| IR per 1000 person-years (95% CI) |
HR (95% CI) Unadjusted |
p-value | aHR (95% CI) Model 1 |
p-value | aHR (95% CI) Model 2 |
p-value | |
|---|---|---|---|---|---|---|---|
| ESKD | |||||||
| Cox Model | 4.74 (4.29, 5.23) | 5.78 (4.43, 7.53) | <0.001 | 2.11 (1.60, 2.80) | <0.001 | 1.44 (1.08, 1.92) | 0.013 |
| Competing Risk Model | -- | 3.57 (1.99, 6.41) | <0.001 | 1.85 (0.98, 3.49) | 0.059 | 1.23 (0.63, 2.42) | 0.550 |
| CHD | |||||||
| Cox Model | 16.2 (15.2, 17.2) | 1.88 (1.46, 2.42) | <0.001 | 1.31 (1.00, 1.70) | 0.046 | 1.12 (0.85, 1.46) | 0.424 |
| Competing Risk Model | -- | 0.77 (0.36, 1.64) | 0.503 | 0.87 (0.40, 1.89) | 0.728 | 0.69 (0.31, 1.52) | 0.357 |
| Stroke | |||||||
| Cox Model | 9.04 (8.44, 9.69) | 1.17 (0.85, 1.60) | 0.342 | 1.04 (0.75, 1.44) | 0.808 | 1.04 (0.75, 1.45) | 0.811 |
| Competing Risk Model | -- | 0.67 (0.35, 1.31) | 0.242 | 0.93 (0.47, 1.82) | 0.826 | -- | |
| Death | |||||||
| Cox Model | 45.0 (47.2, 50.8) | 1.64 (1.40, 1.91) | <0.001 | 1.08 (0.92, 1.26) | 0.360 | 1.18 (1.00, 1.39) | 0.047 |
Competing risk models report subhazard ratios obtained from Fine and Gray subdistribution hazard models.
Model 1: Adjusted for eGFR and UACR.
Model 2: Adjusted for eGFR and UACR + age, sex, race, education, income, insurance status, marital status, urban status, region, hypertension, diabetes, coronary artery disease, stroke, and family history of kidney disease.
CKD – chronic kidney disease; ESKD – end-stage kidney disease; CHD – coronary heart disease; IR – incidence rate; HR – hazard ratio; CI – confidence interval; aHR – adjusted hazard ratio.