TABLE 1.
Vaccine strains and target virus strains used in studies 1 and 2a
| Study and virus | Vaccine strain |
Target virus strain and assay |
||
|---|---|---|---|---|
| TIVc | TIVe | HI | MN | |
| 1 | ||||
| A/H1N1 | A/Brisbane/10/2010 (wild type) (egg-seed/cell-grown) | A/Brisbane/10/2010 (wild type) (egg-seed/egg-grown) | A/Brisbane/10/2010 (egg seed/cell-grown) | A/Brisbane/10/2010 (wild type) (egg-seed/egg-grown) |
| A/H3N2 | NYMC X-223 (reassortant) derived from A/Texas/50/2012 (egg-seed/cell-grown) | NYMC X-223A (reassortant) derived from A/Texas/50/2012 (egg-seed/egg-grown) | A/Texas/50/2012 (X-223A) (egg-seed/cell-grown) | NYMC X-223 (reassortant) derived from A/Texas/50/2012 (egg-seed/cell-grown) |
| B | B/Massachusetts/2/2012 (wild type) (egg-seed/cell-grown) | B/Massachusetts/2/2012 (wild type) (egg-seed/egg-grown) | B/Massachusetts/02/2012 (egg-seed/cell-grown) | B/Massachusetts/2/2012 (wild type) (egg-seed/egg-grown) |
| 2 | aQIV | QIV | HI | MN |
| A/H3N2 | A/Texas/50/2012 (egg-seed/egg-grown) | A/Texas/50/2012 (egg-seed/egg-grown) | A/Texas/50/2012 (X-223) (egg-seed/egg-grown) | A/Texas/50/2012 (X-223) (egg-seed/egg-grown) |
| B | B/Massachusetts/2/2012 (egg-seed/egg-grown) | B/Massachusetts/2/2012 (egg-seed/egg-grown) | B/Massachusetts/2/2012 (BX-51B) (egg-seed/egg-grown) | B/Massachusetts/2/2012 (BX-51B) (egg-seed/egg-grown) |
Abbreviations: aQIV, adjuvanted quadrivalent influenza vaccine; HI, hemagglutination inhibition; MN, microneutralization; QIV, nonadjuvanted quadrivalent influenza vaccine; TIVc, cell-derived trivalent influenza vaccine; TIVe, egg-derived trivalent influenza vaccine. Cell-grown, grown in mammalian cells (Madin-Darby canine kidney [MDCK] cells) in liquid culture as a host for the growing influenza virus. Cell-seed: candidate vaccine virus passaged in cells, provided by WHO GISRS Partner to private sector. Egg-grown, grown in fertilized hen eggs, as a host for the growing influenza virus. Egg-seed: candidate vaccine virus passaged in eggs, provided by WHO GISRS Partner to private sector.