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Global phylogeny of available CNSC genomes. A phylogenetic tree of 84 CNSC genomes (20 from this study and 64 from the NCBI) was generated based on an alignment of 1,842 core genes using RAxML (28). The tree was visualized and annotated using Interactive Tree of Life (iTOL) (29). The tree is annotated based on species, whole-genome sequencing data source, continent of isolation, and carbapenemase genes identified, if any, in the genome of each isolate.
