TABLE 1.
Clinical characteristics of patients with CNSCa
| Isolate ID | Patient age | Gender | Yr | Source | Facility | CNSC | Culture site | Clinical syndrome | Polymicrobial culture | Other organism(s) | Comorbid condition(s) | Outcome of hospitalization |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RS77 | 49 | M | 2018 | Hospital | A | C. freundii | Rectal swab | Colonization | N | None | ESLD, liver transplant | Discharge to home |
| RS102 | 74 | F | 2018 | Hospital | A | C. werkmanii | Rectal swab | Colonization | N | None | ESLD, liver transplant | In-hospital death |
| RS189 | 66 | F | 2017 | Hospital | A | C. werkmanii | BAL fluid | Pneumonia | N | None | Diverticulosis | Discharge to facility |
| RS226 | 56 | F | 2018 | Hospital | A | C. freundii | Urine | Colonization | Y | E. coli | Opiate dependency, CHF, HTN | In-hospital death |
| RS236 | 70 | M | 2018 | Hospital | A | C. freundii | Peritoneal fluid | Intra-abdominal | Y | C. freundii (ESBL), Enterococcus faecium (VRE), Candida tropicalis, Candida parapsilosis | Pancreatic cancer, COPD, DM, HTN | Transfer to hospice |
| RS237 | 80 | F | 2018 | Community | A | C. freundii | Urine | Colonization | N | None | Sinus OM | Discharge to home |
| RS259 | 61 | F | 2018 | Hospital | B | C. freundii | Peritoneal fluid | Intra-abdominal | Y | E. coli, Pseudomonas aeruginosa | Metastatic lung cancer, COPD, DM | In-hospital death |
| RS289 | 92 | M | 2018 | Community | A | C. koseri | Urine | UTI | Y | Enterococcus faecalis | Bladder cancer, dementia, CKD, COPD, CHF | Discharge to home |
| YDC608 | 57 | M | 2013 | Hospital | A | C. freundii | BAL fluid | Colonization | N | None | HLD | Transfer to hospice |
| YDC638-2 | 27 | M | 2013 | Hospital | A | C. freundii | Biliary drainage | Intra-abdominal | Y | E. faecium (VRE) | ESLD, Crohn’s diseases, PSC, liver transplant | Discharge to home |
| YDC645 | 67 | F | 2013 | Hospital | C | C. freundii | Blood | SSTI/Endocarditis | Y | Bacteroides sp., Enterococcus raffinosus | CAD, CHF, DM, ESRD, dementia | Transfer to hospice |
| YDC661 | 64 | M | 2014 | Hospital | A | C. freundii | BAL fluid | Pneumonia | Y | Stenotrophomonas maltophilia | Heart transplant | Discharge to facility |
| YDC667-1 | 73 | M | 2014 | Hospital | A | C. werkmanii | BAL fluid | Pneumonia | Y | K. pneumoniae (ESBL) | CHF, DM, CAD, CKD | In-hospital death |
| YDC689-2 | 61 | M | 2015 | Hospital | A | C. koseri | BAL fluid | Pneumonia | N | None | ESLD, liver transplant | Discharge to facility |
| YDC693b | 65 | M | 2015 | Hospital | A | Citrobacter spp. | BAL fluid | Pneumonia | Y | E. coli (ESBL) | SBT, adrenal insufficiency | In-hospital death |
| YDC697-2b | 65 | M | 2015 | Hospital | A | C. farmeri | Tracheostomy site drainage | SSTI | Y | Klebsiella oxytoca (KPC) | SBT, adrenal insufficiency | In-hospital death |
| YDC730 | 71 | M | 2015 | Hospital | D | C. werkmanii | Pelvic abscess | Intra-abdominal | Y | E. faecium (VRE) | Multiple myeloma | Discharge home |
| YDC849-1 | 26 | F | 2018 | Hospital | A | C. freundii | Urine | UTI | Y | C. freundii (NDM) | CVID | In-hospital death |
| YDC876 | 53 | M | 2019 | Hospital | A | C. freundii | BAL fluid | Pneumonia | N | None | CAD, CHF | Discharge home |
| YDC880 | 73 | M | 2019 | Hospital | A | C. freundii | Rectal swab | Colonization | N | None | Lung transplant | In-hospital death |
Abbreviations: BAL, bronchoalveolar lavage; CAD, coronary artery disease; CHF, congestive heart failure; CKD, chronic kidney disease; CNSC, carbapenem nonsusceptible Citrobacter spp.; COPD, chronic pulmonary disease; CVID, common variable immunodeficiency; DM, diabetes mellitus; ESBL, extended-spectrum beta-lactamase; ESLD, end-stage liver disease; ESRD, end-stage renal disease; F, female; HAP, hospital-acquired pneumonia; HCC, hepatocellular carcinoma; HLD, hyperlipidemia; HTN, hypertension; KPC, Klebsiella pneumoniae carbapenemase; M, male; NDM, New Delhi metallo-beta-lactamase; OM, osteomyelitis; PSC, primary sclerosing cholangitis; SBT, small bowel transplant; SSTI, skin and soft tissue infection; UTI, urinary tract infection; VRE, vancomycin-resistant Enterococcus.
Same-patient isolates.