TABLE 2.
Sensitivity and specificity of PCR/ESI-MS compared with BC in patients with suspected sepsisa
| Species | Sensitivity [no. PCR/ESI-MS+/no. BC+ in % (ratio)] | Specificity [no. PCR/ESI-MS−/no. BC− in % (ratio)] |
|---|---|---|
| Gram-positive bacteria | ||
| Staphylococcus aureus | 70 (19/27) | 99.2 (1,421/1,433) |
| Coagulase-negative staphylococci | 11 (5/45) | 99.6 (1,410/1,415) |
| Streptococcus mitis/Streptococcus pneumoniae | 58 (7/12) | 99.4 (1,440/1,448) |
| Streptococcus pyogenes | 100 (4/4) | 99.9 (1,455/1,456) |
| Streptococcus species | 27 (3/11) | 99.7 (1,445/1,449) |
| Enterococcus faecalis | 57 (4/7) | 99.7 (1,449/1,453) |
| Enterococcus faecium | 100 (6/6) | 98.8 (1,437/1,454) |
| Micrococcus species | 0 (0/1) | 99.6 (1,453/1,459) |
| Cutibacterium acnes | 0 (0/1) | 98.8 (1,442/1,459) |
| Nocardia species | 0 (0/0) | 98.9 (1,444/1,460) |
| Gram-negative bacteria | ||
| Escherichia coli | 93 (50/54) | 94.4 (1,327/1,406) |
| Klebsiella pneumoniae | 80 (20/25) | 98.3 (1,411/1,435) |
| Klebsiella oxytoca | 100 (4/4) | 99.9 (1,454/1,456) |
| Enterobacter cloacae complex | 80 (4/5) | 99.0 (1,441/1,455) |
| Pseudomonas aeruginosa | 100 (5/5) | 99.7 (1,451/1,455) |
| Citrobacter freundii | 0 (0/0) | 99.6 (1,454/1,460) |
| Serratia marcescens | 62 (5/8) | 99.9 (1,451/1,452) |
| Haemophilus influenzae | 0 (0/2) | 99.7 (1,453/1,458) |
| Bacteroides fragilis/Bacteroides thetaiotaomicron | 50 (1/2) | 99.3 (1,448/1,458) |
| Fusobacterium nucleatum | 0 (0/0) | 99.6 (1,454/1,460) |
| Candida species | ||
| Candida albicans | 67 (2/3) | 99.4 (1,448/1,457) |
| Candida glabrata | 0 (0/0) | 99.6 (1,454/1,460) |
a
Species with more than 5 positive results from PCR/ESI-MS and/or BC are included.