TABLE 2.
Primary and secondary outcomes in the preintervention and intervention groups
| Outcome parametera | Preintervention | Intervention | Unadjusted HRb (Cox) or OR (LR)c | Unadjusted P value (Cox or LR)c | Adjustedd HR (Cox) | Adjustedd P value (Cox or LR) |
|---|---|---|---|---|---|---|
| Time to appropriate escalation or de-escalation in h (median [95% CI]) | 52.3 (48.2–60.0) | 42.2 (37.4–48.0) | 1.24 (1.02–1.51) | 0.03 | 1.22 (0.99–1.51) | 0.06 |
| Time to appropriate escalation in h (median [95% CI]) | 46.6 (37.9–64.4) | 45.0 (33.0–60.7) | 1.23 (0.96–1.57) | 0.1 | 1.28 (0.98–1.68) | 0.08 |
| Time to appropriate de-escalation in h (median [95% CI]) | 52.2 (47.5–60.6) | 43.4 (37.4–54.5) | 1.27 (0.92–1.74) | 0.1 | 1.17 (0.83–1.65) | 0.4 |
| Time to oral antibiotic stepdown in h (median [95% CI]) | 105.8 (87.2–147.4) | 132.3 (102.8–195.7) | 0.92 (0.74–1.14) | 0.4 | 0.87 (0.69–1.10) | 0.2 |
| LOS in h (median [95% CI]) | 96.1 (86.0–107.2) | 115.2 (99.8–127.9) | 1.02 (0.87–1.19) | 0.8 | 0.92 (0.77–1.09) | 0.4 |
| 30-day all-cause mortality (no. [%]) | 24 (7.1) | 16 (4.8) | 0.65 (0.34–1.25) | 0.2 | 0.83 (0.39–1.77) | 0.6 |
| 7-day AKI incidence (no. [%]) | 58 (17.3) | 44 (13.1) | 0.72 (0.47–1.11) | 0.1 | 0.82 (0.51–1.31) | 0.4 |
| 30-day C. difficile incidence (no. [%]) | 7 (2.1) | 6 (1.8) | 0.86 (0.29–2.58) | 0.8 | 1.08 (0.32–3.60) | 0.9 |
a
AKI, acute kidney injury; CI, confidence interval; LOS, length of stay.
b
HR, hazard ratio; Cox, Cox proportional hazards model.
c
OR, odds ratio; LR, logistic regression.
d
Adjusted for age, sex, Charlson comorbidity index, empirical active therapy, infection source, and febrile neutropenia.