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. 2020 Aug 24;58(9):e00311-20. doi: 10.1128/JCM.00311-20

TABLE 4.

Clinical investigation of cases rejected for FilmArray ME panel testing due to normal CSF WBC counts but positive with a conventional test

Conventional test result Clinical comorbidity(ies)a Treatment decision Impacts of ME panel rejection
HHV-6 detected Lymphoma, status post-BMT Foscarnet started Diagnosis delayed 18 h,b treatment delayed 22 hb
HHV-6 detected MDS, status post-BMT Foscarnet started Diagnosis delayed 133 h,b treatment delayed 136 hb
CMV detected CNS vasculitis, on immunosuppressive therapy Ganciclovir started Diagnosis delayed 44 h,b treatment delayed 46 hb
VZV detected Status post-liver transplant Acyclovir continued Diagnosis delayed 32 h,b no treatment delay
a

BMT, bone marrow transplant; MDS, myelodysplastic syndrome; CNS, central nervous system.

b

Assumes that the Film Array ME panel would have detected the target detected by the conventional assay.