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. Author manuscript; available in PMC: 2020 Aug 26.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2019 Dec 23;29(2):509–519. doi: 10.1158/1055-9965.EPI-18-1359

Figure 4: Stromal content’s association with overall survival.

Figure 4:

These forest plots examine association with overall survival across ovarian cancer studies (n=16) using A) the AOCS tumor and stromal gene signatures or B) only the genes that were specific to tumor-associated stroma from the MGH study. The two TCGA gene expression datasets are n=510 Affymetrix HT_HG-U133A and n=256 Illumina HiSeq RNA sequencing. C) Kaplan-Meier curves of pathologist assessment of percent stroma (cutoff of 30%) in high stage TCGA tumors (HR 1.01 for each percent increase in stromal content, CI 1.0–1.02, p=0.024). A 30% stroma threshold is shown since it is between the original TCGA consortium tumor purity threshold of at least 80% and the later reduced threshold of 60% tumor cells.