Table 1.
Laboratory Values∗
| Laboratory Test | Reference Range | Day 1 | Day 4 | Day 7 | Day 9 | Day 11 | Day 18 |
|---|---|---|---|---|---|---|---|
| WBC count, ×103/mm3 | 3.90-10.60 | 1.61 | 1.58 | 14.81 | 5730 | 5.58 | 4.37 |
| Lymphocyte count, ×103/mm3 | 0.70-5.00 | 0.58 | 0.21 | NA | 0.65 | 0.87 | 1.02 |
| Neutrophil count, ×103/mm3 | 1.50-8.00 | 0.88 | 1.21 | NA | 4.42 | 3.75 | 2.17 |
| Platelet count, ×103/mm3 | 150-400 | 104 | 37 | 167 | 197 | 251 | 233 |
| CPR, mg/L | 0.0-5.0 | 195 | 225.16 | 212 | 131 | 37 | 2.99 |
| Ferritin, ng/mL | 21-246 | NA | NA | 7864 | NA | NA | 1439 |
| IL-6, ng/L | 0.0-7.0 | NA | 101.6 | NA | NA | NA | 139.8 |
| LDH, U/L | <248 | NA | 276 | NA | NA | 454 | NA |
Abbreviations: CPR = C-reactive protein; IL-6 = interleukin-6; LDH = lactate dehydrogenase; NA = not available; TCZ = tocilizumab; WBC = white blood cell.
∗
First dose of TCZ on day 8 and second dose of TCZ on day 9.